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Fig. 1 | Clinical and Translational Medicine

Fig. 1

From: The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment

Fig. 1

The classification of extracellular vesicles. EVs contain various molecules, such as miRNAs, mRNAs, DNAs, proteins and lipids. Exosomes are formed by inward budding into early endosomes to form MVBs. This inward budding process involves ceramide-dependent mechanisms or an ESCRT. Subsequently, these MVBs fuse with the limiting plasma membrane to release exosomes into the extracellular space. This fusion process is dependent on Rab GTPases (e.g., Rab27A/B). MVs are directly shed or bud from the plasma membrane. Apoptotic bodies are released from the cell undergoing programmed cell death. Pri-miRNA: primary microRNA

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