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Table 9 Results of real time quantitative PCR analysis on 10 CNV/SV regions predicted by NGS to be unshared between twins

From: Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Gene/region Chr Start End Size (bp) Family Type NGS prediction Real time result in affected twin Difference between twins? Buccal DNA
GABRD 1 825765 5726936 4,901,171 1 SV Increase 2.62 Yes (2.65)
CLSTN2 3 139670597 139674454 3857 2 SV Increase 1.16 No (1.64)
OPRM1 6 154446930 154447253 323 2 SV Decrease 2.15 N/A
STX1A 7 66193913 73382120 7,188,207 1 SV Decrease 2.75 No (1.98)
12q24.21 12 114521470 114529470 8000 2 CNV Increase 1.33 Yes (0.82)
ANKS1B 12 99793948 99802771 8823 1 SV Decrease 1.9 N/A
15q11.2 15 22422114 22492114 70,000 1 CNV Increase 2.69 Yes (2.58)
CES1 16 55841801 55855801 14,000 1 CNV Increase 1.56 N/A
16p11.2 16 34467150 34515150 48,000 1 CNV Increase 1.8 N/A
PLTP 20 44535505 44535941 436 1 SV Decrease 2.1 N/A