Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Clinical and Translational Medicine

Table 8 Shared and unshared structural variation (SV) as compared to NCBI Build 37

Sample	Total SVs	Shared with co-twin	Unshared with co-twin	Shared with co-twin		Unshared with co-twin
Sample	Total SVs	Shared with co-twin	Unshared with co-twin	Inherited	De novo	Inherited	De novo
Family 1 affected (I-2-1)	919	781	138	750	31	97	41
Family 1 unaffected (I-2-2)	893	781	112	750	31	66	46
Family 2 affected (II-2-1)	996	855	141	N/A	N/A	N/A	N/A
Family 2 unaffected (II-2-2)	977	855	122	N/A	N/A	N/A	N/A

Structural variants fell under five categories: deletions, tandem duplications, distal duplications, inter-chromosomal variations and inversions. There were no inversion differences found between twins in either family. They were not included in subsequent analyses