Skip to main content

Table 11 Genes affected in two pathways (glutamate receptor signaling and dopamine feedback in cAMP signaling) unique to the two unrelated schizophrenia patients representing family 1 and family 2

From: Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Pathway Family 1: genes in pathway Family 2: genes in pathway Common to both affected twins
Number of genes affected Identity Number of genes affected Identity
Dopamine feedback in cAMP signaling 29 PRKG2, PPP2R1U, GUCY1A3, PRKAG2, ADCY3, PRKCB, PRKAR1B, KCNJ12, ADCY2, PRKCZ, ADCY8, PLCL1, CACNA1D, DRD3, PLCB1, GUCY1A2, EP300, PRKG1, PPP3CA, CACNA1A, GRIN2U, PLCG2, KCNJ3, PRKCA, PLCH2, CACNA1C, PLCL2, PLCZ1, KCNJ10 23 PLCB1, PRKG2, PRKG1, PPM1L, CAMK4, PLCE1, PRKAG2, PPP2R2C, ADCY10, PPP1R14C, GRIN2A, CREB5, PRKCA, CACNA1C, PRKCB, KCNJ12, ITPR1, PRKAR1B, PRKCI, PRKCZ, ADCY8, PRKCG, DRD3 12
(PRKG2, PRKAG2, PRKCB, PRKAR1B, KCNJ12, PRKCZ, ADCY8, DRD3, PLCB1, PRKG1, PRKCA, CACNA1C)
Glutamate receptor signaling 13 GRIA1, GRIK2, GRID1, GNB1, GRIN2U, SLC1A7, GRIK1, GRIK4, GRM7, GRM1, GRM5, GRM8, GRIK3 15 GRID1, GNG7, CAMK4, SLC1A2, HOMER1, SLC1A7, GRIK1, GRIN2A, GRM4, GRIK4, SLC1A1, GRM7, GNG2, GRM5, GRM6 6
(GRID1, SLC1A7, GRIK1, GRIK4, GRM7, GRM5)