Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Clinical and Translational Medicine

Table 11 Genes affected in two pathways (glutamate receptor signaling and dopamine feedback in cAMP signaling) unique to the two unrelated schizophrenia patients representing family 1 and family 2

Pathway	Family 1: genes in pathway		Family 2: genes in pathway		Common to both affected twins
Pathway	Number of genes affected	Identity	Number of genes affected	Identity	Common to both affected twins
Dopamine feedback in cAMP signaling	29	PRKG2, PPP2R1U, GUCY1A3, PRKAG2, ADCY3, PRKCB, PRKAR1B, KCNJ12, ADCY2, PRKCZ, ADCY8, PLCL1, CACNA1D, DRD3, PLCB1, GUCY1A2, EP300, PRKG1, PPP3CA, CACNA1A, GRIN2U, PLCG2, KCNJ3, PRKCA, PLCH2, CACNA1C, PLCL2, PLCZ1, KCNJ10	23	PLCB1, PRKG2, PRKG1, PPM1L, CAMK4, PLCE1, PRKAG2, PPP2R2C, ADCY10, PPP1R14C, GRIN2A, CREB5, PRKCA, CACNA1C, PRKCB, KCNJ12, ITPR1, PRKAR1B, PRKCI, PRKCZ, ADCY8, PRKCG, DRD3	12 (PRKG2, PRKAG2, PRKCB, PRKAR1B, KCNJ12, PRKCZ, ADCY8, DRD3, PLCB1, PRKG1, PRKCA, CACNA1C)
Glutamate receptor signaling	13	GRIA1, GRIK2, GRID1, GNB1, GRIN2U, SLC1A7, GRIK1, GRIK4, GRM7, GRM1, GRM5, GRM8, GRIK3	15	GRID1, GNG7, CAMK4, SLC1A2, HOMER1, SLC1A7, GRIK1, GRIN2A, GRM4, GRIK4, SLC1A1, GRM7, GNG2, GRM5, GRM6	6 (GRID1, SLC1A7, GRIK1, GRIK4, GRM7, GRM5)