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Fig. 7 | Clinical and Translational Medicine

Fig. 7

From: Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Fig. 7

a Dopamine feedback in cAMP signaling pathway identified using ingenuity pathway analysis (IPA). Genes that were unique to each affected twin were used to generate canonical pathways of interest. This pathway emerged independently in both affected twins. This pathway was also not found to be enriched in unaffected twins in the study. Purple represents genes harboring a unique high confidence variant in each respective patient (family 1, p = 2.28E−04; family 2, p = 5.84E−03). b Glutamate pathway identified using ingenuity pathway analysis (IPA). Genes that were unique to each affected twin were used to generate canonical pathways of interest. This pathway emerged independently in both affected twins. This pathway was also not found to be enriched in unaffected twins in the study. Purple represents genes harboring a unique high confidence variant in each respective patient (family 1, p = 1.46E−03; family 2, p = 3.88E−05)

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