Fig. 2

Retinal architecture and cellular relationships. a The retina is a laminar structure where the cell bodies of cone and rod photoreceptors (PRs) are located in the outer nuclear layer (ONL), horizontal cells (HCs), bipolar cells (BCs), and amacrine cells (ACs) are located in the inner nuclear layer (INL), and ganglion cells (GCs) are situated in the ganglion cell layer (GCL). These nuclear layers are interspersed by the outer and inner plexiform layers (OPL/IPL) containing the neural connections. b Transplantation strategies in zebrafish allow visualization of the clonal expansion performed by a single retinal progenitor cell (RPC) of the optic cup. Here, H2B-GFP is used to label all cells while Ptf1a-dsRed marks horizontal and amacrine cells [43]. These results demonstrate the multipotency of RPCs and highlight the close relationship between some cell types. c Additional studies have shown that horizontal cells and photoreceptors often share a common progenitor. The lineage also visualizes the different types of cells where retinoblastoma may arise