Table 1 Patients with hormone positive metastatic breast cancer treated with dovitinib
Pt # | Age | Index lesion tumor size at baseline (cm) | Aromatase inhibitor | Total # cycles of dovitinib | Dovitinib dose (mg) | AE after first cycle | Change in tumor size after 8 weeks dovitinib (%) | Sites of metastases |
|---|---|---|---|---|---|---|---|---|
001 | 61 | 6.5 | Exemestane | 6 | 500 | Fatigue GI: nausea, dry mouth Neuromusc: myalgia, dizziness | − 9.23 | Lymph nodes, bone, skin/soft tissue |
002 | 32 | 15 | Anastrozole | 1 | 500 | Fatigue GI: nausea, vomiting, diarrhea, dehydration, poor appetite Neuromusc: headaches, blurred vision, lightheadedness Liver: ALP↑ | + 6.0 | Lymph nodes, lung, bone |
004 | 65 | 2.9 | Letrozole | 2 | 400 | Fatigue, hypertension, bone pain GI: anorexia, nausea, dyspepsia | + 24.14 | Lung, liver |
005 | 58 | 5.7 | Exemestane | 3 | 400 | Fatigue GI: nausea, vomiting, anorexia, dysgeusia Neuromusc: muscle weakness Liver: ALP↑, AST↑ | + 24.56 | Lymph nodes, soft tissue, liver |
101 | 64 | 1 | Anastrozole | 4 | 500 | Serum amylase↑, creatine↑, magnesium↑ Liver: GGT↑ | − 30.0 | Lymph nodes, bone |
102 | 57 | 4.8 | Letrozole | 2 | 400 | GI: nausea Liver: GGT↑ | 0 | Lymph nodes, bone |
103 | 52 | 13.1 | Anastrozole | 7 | 400 | GI: diarrhea Neuromusc: back pain Liver: GGT↑, ALT↑, ALP↑ | − 21.37 | Lymph nodes, bone, pleura, liver |
301 | 51 | 1 | Letrozole | 3 | 400 | Hypokalemia GI: diarrhea, dyspepsia Neuromusc: arthralgia Liver: triglycerides↑, ALT↑, ALP↑, GGT↑ Anemia, Cholesterol↑ | + 10 | Lung |