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Clinical and Translational Medicine
Fig. 1 | Clinical and Translational Medicine

Fig. 1

From: Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib

Fig. 1

Breast cancer lesion sizes, treatment responses and design of the miR analysis. a Patient numbers are color coded to indicate changes in tumor sizes after 8 weeks of treatment (red = increase, green = decrease, grey = no change). The sizes of the index lesions were measured by CT before treatment with dovitinib (baseline). b Change in tumor size of the index lesion during the course of dovitinib treatment. c Flow chart of plasma miR analysis design. From a genome wide miR expression array with samples collected before and after dovitinib treatment in a single patient, 6 signature miRs were selected and tested for their indication of a dovitinib response in 8 patients. Further criteria for selection of the miRs are provided in the “Results” section

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