Fig. 7
From: The role of heterogeneity in asthma: a structure-to-function perspective
(reproduced with permission from [15])
Overview of image functional modeling. a Terminal units are defined from the airway tree model which are subsequently mapped to the ventilation defects obtained from HP 3He MRI with ventilated terminal units depicted in blue and the nonventilated terminal units depicted in yellow. b Through a recursive algorithm, the largest airway is determined and designated for closure depicted in red. c Constriction patterns are applied to the airway tree model to best match measured RL and EL