| |
Unadjusted
|
Adjusted
|
|---|
|
Exp(B) (95% CI)
|
pa
|
Exp(B) (95% CI)
|
pb
|
|---|
|
rs10336 AG
|
|
LSM (kPa)
|
0.82 (0.73; 0.92)
|
0.001
|
0.85 (0.76; 0.95)
|
0.005
|
|
F ≥ 2 (≥7.1)
|
0.55 (0.37; 0.83)
|
0.004
|
0.59 (0.38; 0.91)
|
0.016
|
|
F ≥ 3 (≥9.5)
|
0.48 (0.31; 0.74)
|
0.001
|
0.54 (0.34; 0.86)
|
0.010
|
|
F4 (≥12.5)
|
0.52 (0.31; 0.89)
|
0.016
|
0.56 (0.32; 0.98)
|
0.043
|
|
rs3921 CG
|
|
LSM (kPa)
|
0.82 (0.73; 0.91)
|
<0.001
|
0.84 (0.76; 0.94)
|
0.003
|
|
F ≥ 2 (≥7.1)
|
0.53 (0.35; 0.79)
|
0.002
|
0.56 (0.36; 0.86)
|
0.008
|
|
F ≥ 3 (≥9.5)
|
0.49 (0.32; 0.76)
|
0.002
|
0.55 (0.34; 0.88)
|
0.013
|
|
F4 (≥12.5)
|
0.54 (0.31; 0.91)
|
0.021
|
0.57 (0.33; 1.00)
|
0.051
|
|
rs4619915 AG
|
|
LSM (kPa)
|
0.82 (0.73; 0.91)
|
<0.001
|
0.84 (0.76; 0.94)
|
0.003
|
|
F ≥ 2 (≥7.1)
|
0.53 (0.35; 0.79)
|
0.002
|
0.56 (0.36; 0.86)
|
0.008
|
|
F ≥ 3 (≥9.5)
|
0.49 (0.32; 0.76)
|
0.002
|
0.55 (0.34; 0.88)
|
0.013
|
|
F4 (≥12.5)
|
0.54 (0.31; 0.91)
|
0.021
|
0.57 (0.33; 1.00)
|
0.051
|
-
Exp(B) geometric mean ratio (GMR) continuous variable or odds ratio (OR) for categorical variables, 95%CI 95% of confidence interval, p value level of significance, LSM liver stiffness measure, kPa kilopascal, F ≥ 2 significant fibrosis, F ≥ 3 advance fibrosis, F4 cirrhosis, HCV-GT hepatitis C virus genotype, CXCL chemokine (C-X-C motif) ligand
- Statistical: a p values were calculated by univariate regression
-
bp values were calculated by multivariate regression adjusted by the most important clinical and epidemiological characteristics (see “statistical analysis” section). Statistically significant differences are shown in italic
