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Clinical and Translational Medicine
Fig. 3 | Clinical and Translational Medicine

Fig. 3

From: Phosgene-induced acute lung injury (ALI): differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine

Fig. 3

The left column compares time-course changes of endpoints suggestive of pulmonary edema (protein and soluble collagen in BALF, wet weight of excised lungs). Associated changes in cellular endpoints (TCC, PMN and alveolar macrophages in BALF) are shown in the right column. Rats were exposed to air (control) or phosgene at the non-LCt01 of ≈1000 mg/m3 × min. Time-course changes were examined by serial sacrifices on post-exposure days 1, 7, 14, and 28 (phosgene only). Data points represent means ± SD (six rats per group and time point). Asterisks (*) denote significant differences to the time-matched air control group (*P < 0.05, **P < 0.01)

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