Fig. 2
From: ETS-targeted therapy: can it substitute for MEK inhibitors?
The complex containing RFWD2/COP1 mediates ubiquitination of ETS1. The E3 ubiquitin ligase RFWD2/COP1 recognizes ETS1 in a CAMK2-mediated Ser276 and Ser282 phosphorylation-dependent manner. Src or YES1 phosphorylates ETS1 at Tyr283, which reverses CAMK2-dependent destabilization of ETS1 protein. The deubiquitinase USP9X prevents EST1 ubiquitination and stabilizes the protein. Thus, dasatinib and WP1130 (Src and USP9X inhibitors, respectively) might target ETS1 for proteolysis