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Clinical and Translational Medicine
Fig. 1 | Clinical and Translational Medicine

Fig. 1

From: Can glypican-3 be a disease-specific biomarker?

Fig. 1

Positive and negative effects of GPC3 on its two main signaling pathways. In the Wnt signaling pathway (left), GPC3 suppresses canonical Wnt signaling pathway (Wnt/β-catenin) while motivating the activation of non-canonical Wnt signaling pathway (Wnt/JNK). In the Hedgehog (Hh) signaling pathway (right), this signaling pathway can be triggered by combination of Hh and the receptor Patched (Ptc) which leads to the inhibition of Ptc on Smoothened. GPC3 competes with Ptc for Hh binding

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