From: Pharmacokinetics of oseltamivir in infants under the age of 1 year
Patient number | Age months (m) and days (d) | Comorbidities | Clinical AE | Laboratory changes |
---|---|---|---|---|
1 | 6 m, 23 d | Tetralogy of Fallot | D1 Dry-retching | Day 1 bloods: raised creatinine (48 mmol/L) and AST (66 mmol/L) Attributed to cardiac condition Normalised after frusemide dose during course of oseltamivir |
2 | 5 m, 13 d | Albright’s osteodystrophe Hypothyroidism Hypoparathyroidism GORD Severe OSA due to epiglottis dystrophy | Nil | Nil |
3 | 11 m, 15 d | Streptococcus pneumoniae bacteraemia, pneumonia, meningitis Parainfluenza 3/rhinovirus/enterovirus co-infection Developed HUS | Nil | Baseline bloods normal D2 of oseltamivir: rising creatinine, urea, AST/ALT/GGT All parameters normalised 10 days after first dose Laboratory abnormalities attributed to HUS |
4 | 3 m, 13 d | Exomphthalmos | Nil | Nil |