Fig. 4

HDM-induced MMP-7 protein and gene expression is attenuated by CC-930. a MMP-7 immunohistochemistry staining of mouse lungs exposed to PBS, HDM alone, HDM + vehicle, or HDM + CC-930 (magnification: 200×). b Evaluation of total MMP-7 protein in BALF and c serum measured by the enzyme-linked immunosorbent assay and d mRNA expression of MMP-7 in lung homogenates measured by q-PCR mice after PBS or HDM exposure. Data shown represents mean ± SEM from two independent experiments (PBS: n = 10; HDM alone: n = 10; HDM + vehicle control: n = 11; HDM + CC-390: n = 11). *P < 0.05 (analysis of variance) versus PBS. ^† P < 0.05 versus the HDM + vehicle group