Fig. 3

Impact of CC-930 or vehicle on HDM-induced fibrotic airway remodeling. a Histopathological analysis of Masson’s trichrome-stained airway sections in mice exposed to PBS, HDM alone, HDM + vehicle, or HDM + CC-930 (magnification: 200×). Assessment of total collagen content by b sircol and c hydroxyproline assay in the upper right lobe of mice after PBS, HDM alone, HDM + vehicle, or HDM + CC-930 exposure. Assessment of mRNA abundance of d collagen 1A1 and e collagen 4, collagen 5, and mRNA abundance was normalized to β-actin. Results are expressed as fold change compared with PBS-exposed mice and reflect mean ± SEM from two independent experiments (PBS: n = 10; HDM alone: n = 10; HDM + vehicle control: n = 11; HDM + CC-930: n = 11). *P < 0.05 (analysis of variance) versus PBS. ^† P < 0.05 compared with the HDM group