Fig. 2
From: JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers
Effect of CC-930 or vehicle on HDM-induced mucus metaplasia. a Periodic acid-Schiff staining of airway mucus in mice exposed to PBS, HDM alone, HDM + vehicle, or HDM + CC-930 (magnification: 200×). Quantification of mRNA levels for b MUC5AC and c MUC5B in lung tissue homogenates by q-PCR after PBS or HDM exposure. d MUC5B immunofluorescent (red) and club cell secretory protein (green) staining of mouse lungs exposed to PBS, HDM alone, HDM + vehicle, or HDM + CC-930. Nuclei were stained using DAPI (blue) (magnification: 200×). Data shown represents mean ± SEM from two independent experiments (PBS: n = 10; HDM alone: n = 10; HDM + vehicle control: n = 11; HDM + CC-930: n = 11). *P < 0.05 (analysis of variance) versus PBS