Fig. 2
From: Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?
Schematic representation of the role of chronic inflammation in aging and induction of immune tsunami in multistep carcinogenesis. The overall scheme shows that loss of balance in tumoricidal (Yin) and tumorigenic (Yang) properties of protective acute inflammation (effective immunity) is associated with mismatched exaggerated expression and co-expression of apoptotic and wound healing factors. Circulating histamine release at low levels is hypothesized to play important roles in the induction of tumorigenesis and angiogenesis (see text)