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Fig. 1 | Clinical and Translational Medicine

Fig. 1

From: Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?

Fig. 1

Schematic representation of maintenance of Yin vs. Yang (tumoricidal vs. tumorigenic) of acute inflammation in health (left panel, Yin = Yang) or the induction of oxidative stress in alterations of intrinsic and extrinsic factors [e.g., loss of mitochondrial function (mitophagy) or ribosomal function (autophagy), accumulation of oxidants (ROS/RNS), mutated genes (DNA/RNA) immune suppression (changes in CMI/HI)] toward increased risk of chronic diseases (e.g., asthma/emphysema, diabetes and cardiovascular diseases or cancer and angiogenesis) during aging process (right panel); see text

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