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Table 1 IMS proteins related to apoptosis induction

From: Mitochondria, cholesterol and cancer cell metabolism

IMS protein

MW (kDa)

Function

References

Cytochrome c

12

Apaf-1 binding and apoptosome initiation

[49, 54, 56]

SMAC/DIABLO

23

Neutralization of apoptosis inhibitor factors

[49, 56, 57]

OMI/HTRA2

37

Neutralization of apoptosis inhibitor factors

[49, 58]

AIF

62

DNA fragmentation

[56, 59]

ENDOG

28

DNA fragmentation

[55]

AK2, Adenylate Kinase 2

26

Initiation of AK2-FADD-caspase-10 complex

[60]