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Clinical and Translational Medicine
Fig. 9 | Clinical and Translational Medicine

Fig. 9

From: Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency

Fig. 9

Pleural inflammation and lavage neutrophilia is increased in PAI-1 deficiency after induction of S. pneumoniae mediated pleural injury. Pleural injury was induced in WT and PAI-1−/− mice by intrapleural injection of S. pneumoniae for 3 days. PLs from saline and S. pneumoniae-infected WT and PAI-1−/− mice demonstrated significant increases in KC, IL-4, IL-5, IL-6, IL-10, IL-12, MCP-1, G-CSF, and MIP-1β * denotes P < 0.05, n = 4–7 mice/group). S. pneumoniae infection significantly decreased IL-13 in WT mice (p < 0.05) when compared to controls. Saline-treated PAI-1−/− mice demonstrated significantly less IL-13 than similarly treated WT mice (p < 0.05). n = 4–7 mice/group

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