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Fig. 7 | Clinical and Translational Medicine

Fig. 7

From: Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency

Fig. 7

Mice with S. pneumoniae empyema demonstrate increased α-SMA in the mesothelium of the visceral pleura. Peripheral lung tissue sections from saline and S. pneumoniae-infected mice were prepared from the lungs of mice with empyema that progressed over 7 days. The sections were then probed for calretinin (green) and α-SMA (red) expression in the pleural mesothelium and observed by confocal microscopy. Solid arrows indicate areas of α-SMA and calretinin colocalization at the surface and within the thickened visceral pleura of S. pneumoniae infected mice. All images were taken at 40× magnification. Images are representative of 30 fields/slide and n = 5–6 mice/group

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