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Fig. 10 | Clinical and Translational Medicine

Fig. 10

From: Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency

Fig. 10

PGE2 and plasmin levels are increased in PAI-1 deficiency after induction of S. pneumoniae mediated pleural injury. Pleural injury was induced in WT and PAI-1−/− mice by intrapleural injection of S. pneumoniae and maintained for 3 days. PGE2 was extracted from the PLs of saline and S. pneumoniae-infected mice. PGE2 levels were then determined by competitive ELISA. a PGE2 was significantly higher in S. pneumoniae infected PAI-1−/− mice compared to infected WT mice at 3 days, n = 4–7 mice/group. * denotes (P < 0.05). b PLs from saline and S. pneumoniae infected WT and PAI-1−/− mice were assayed for plasmin activity. S. pneumoniae infection significantly increased plasmin activity in WT and PAI-1−/− mice (p = 0.05 and 0.02, respectively) by 3 days. S. pneumoniae-infected PAI-1−/− mice demonstrated significantly higher plasmin activity than identically treated WT mice (p = 0.04)

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