Table 1 Mitochondrial transplantation
Tissue | Heart | Heart | Liver | Brain |
|---|---|---|---|---|
Animal model | Rabbit | Rabbit | Rat | Rat |
Experimental model | Langendorff perfused heart | In situ, blood perfused | In situ, blood perfused | In situ brain |
Injury model | Ischemia/reperfusion | Ischemia/reperfusion | Ischemia/reperfusion | Parkinson’s disease |
Mitochondria | Unmodified | Unmodified | Unmodified | Conjugated with PEP-1 |
Delivery | Direct injection | Direct injection | Direct injection | Direct injection |
Outcome | Enhanced myocardial function following ischemia, enhanced cell viability | Enhanced myocardial function following ischemia, enhanced cell viability | Decreased liver tissue injury and apoptosis | Peptide-mediated mitochondrial transplantation lessened Parkinson’s disease movement disorder and attenuated the deterioration of dopaminergic neurons |
Reference | McCully et al. [20] | Masuzawa et al. [19] | Lin et al. [51] | Chang et al. [50] |