Fig. 7From: Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell diseaseHydroxyurea mechanisms of HbF induction: regulators and miRNAs mediated actions. Proposed HU-induced miRNAs-mediated mode of indirect HbF regulation through critical regulators (MYB/KLF-1/BCL11A) and possibly directly modulating HbFBack to article page