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Clinical and Translational Medicine
Fig. 4 | Clinical and Translational Medicine

Fig. 4

From: Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease

Fig. 4

Hydroxyurea induces differential expression of miRNAs associated with BCL11A and MYB repression in erythroid cells. Treatment of primary cells with HU causes differential regulation of miRNAs as early as 6 h post treatment. There is inter-individual variation in expression however, miR-26b was significantly down-regulated in all but one primary lines. And conversely, miR-451 is down-regulated in all but 1 of the erythroid lines. HU induces variation in the expression of miRNAs associated with key regulators of HbF. * Significant difference, p < 0.05

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