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Clinical and Translational Medicine
Fig. 3 | Clinical and Translational Medicine

Fig. 3

From: Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease

Fig. 3

Hydroxyurea-induced gene expression changes in ex vivo derived erythroid cells. The gene expression profiles of primary erythroid lines after HU treatment for 6 h. Although the expected inter-individual variation in expression was observed, there were several common trends such the low BCL11A, KLF-1 and MYB; and significant upregulation of HbF expression. HBB (β-globin) expression was always associated with BCL11A, which is expected given the role of this transcription factor in the “fetal switch”. * Significant difference, p < 0.05

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