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Clinical and Translational Medicine
Fig. 2 | Clinical and Translational Medicine

Fig. 2

From: Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease

Fig. 2

Time-dependent gene expression changes in K562 cells treated with hydroxyurea Hydroxyurea induced inverse time-dependent sigmoidal expression of BCL11A and HBG-1 (HbF) with the highest fold increase in HbF corresponding to the lowest BCL11A expression between 6 and 12 h after HU treatment. KLF-1, an activator of BCL11A, also followed a similar trend, lowest after 12 h of HU treatment. GATA-1 was also down-regulated at the same time point as well as the negative regulator, MYB. * Significant difference, p < 0.05

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