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Clinical and Translational Medicine
Fig. 1 | Clinical and Translational Medicine

Fig. 1

From: Depurinating estrogen-DNA adducts, generators of cancer initiation: their minimization leads to cancer prevention

Fig. 1

Common mechanism of metabolic activation and reaction with DNA to form the N3Ade and N7Gua depurinating adducts for benzene, naphthalene, estrone (E1), estradiol (E2), diethylstilbestrol (DES), and hexestrol (HES). The figure shows the progression from parent compound to hydroxy derivative, catechol, and then quinone, which reacts with DNA to form the depurinating adducts at the N3Ade and N7Gua

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