Fig. 4

Model of pathway-centric personalized medicine. Green and grey rectangles indicate drug effector and drug non-effector pathways, respectively; red and white circles represent individually altered and wildtype genes, respectively; normal and bold lines indicate normal and ectopic activated pathway signalling, respectively; and flash signs indicate drugs targeting specific molecules. One case with good drug effect, two cases with no drug effect, and two cases with partial drug effect are demonstrated.