Table 3 Top 14 candidate protein drug targets of Mycobacterium tuberculosis H37Rv
Gene Symbol | Locus | Functional class | Max-flow | Cross reference (PDB) |
|---|---|---|---|---|
rpoA | Rv3457c | information pathways | 70861 | |
rpsC | Rv0707 | information pathways | 61418 | |
rplJ | Rv0651 | information pathways | 61319 | |
secY | Rv0732 | cell wall and cell processes | 49050 | |
gdh | Rv2476c | intermediary metabolism and respiration | 36008 | |
katG | Rv1908c | virulence, detoxification, adaptation | 33297 | 1SFZ;1SJ2;2CCA;2CCD;4C50;4C51; |
glcB | Rv1837c | intermediary metabolism and respiration | 31666 | 2GQ3;3S9I;3S9Z;3SAD;3SAZ;3SB0; |
hisD | Rv1599 | intermediary metabolism and respiration | 30402 | |
korA | Rv2455c | intermediary metabolism and respiration | 27638 | |
rpoZ | Rv1390 | information pathways | 27485 | |
gltB | Rv3859c | intermediary metabolism and respiration | 26942 | |
dnaN | Rv0002 | information pathways | 24226 | 3P16;3RB9; |
sirA | Rv2391 | intermediary metabolism and respiration | 23588 | 1ZJ8;1ZJ9; |
ftsZ | Rv2150c | cell wall and cell processes | 23472 | 1RLU;1RQ2;1RQ7;2Q1X;2Q1Y;4KWE; |