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Table 3 Top 14 candidate protein drug targets of Mycobacterium tuberculosis H37Rv

From: Maximum flow approach to prioritize potential drug targets of Mycobacterium tuberculosis H37Rv from protein-protein interaction network

Gene Symbol Locus Functional class Max-flow Cross reference (PDB)
rpoA Rv3457c information pathways 70861  
rpsC Rv0707 information pathways 61418  
rplJ Rv0651 information pathways 61319  
secY Rv0732 cell wall and cell processes 49050  
gdh Rv2476c intermediary metabolism and respiration 36008  
katG Rv1908c virulence, detoxification, adaptation 33297 1SFZ;1SJ2;2CCA;2CCD;4C50;4C51;
glcB Rv1837c intermediary metabolism and respiration 31666 2GQ3;3S9I;3S9Z;3SAD;3SAZ;3SB0;
hisD Rv1599 intermediary metabolism and respiration 30402  
korA Rv2455c intermediary metabolism and respiration 27638  
rpoZ Rv1390 information pathways 27485  
gltB Rv3859c intermediary metabolism and respiration 26942  
dnaN Rv0002 information pathways 24226 3P16;3RB9;
sirA Rv2391 intermediary metabolism and respiration 23588 1ZJ8;1ZJ9;
ftsZ Rv2150c cell wall and cell processes 23472 1RLU;1RQ2;1RQ7;2Q1X;2Q1Y;4KWE;