Clinical and Translational Medicine

Table 7 Performance of markers in primary and metastatic lung adenocarcinomas by bootstrap analysis

From: Utility of five commonly used immunohistochemical markers TTF-1, Napsin A, CK7, CK5/6 and P63 in primary and metastatic adenocarcinoma and squamous cell carcinoma of the lung: a retrospective study of 246 fine needle aspiration cases

Markers	Sensitivity		Specificity
Markers	Average ± SD	Range	Average ± SD	Range
Primary ADCs
TTF-1	0.848 ± 0.0446	0.690 – 0.972	0.934 ± 0.0438	0.800 – 1.000
Napsin A	0.919 ± 0.0545	0.720 – 1.000	1.000 ± 0.0000	1.000 – 1.000
CK7	0.941 ± 0.0330	0.833 – 1.000	0.489 ± 0.1432	0.077 – 0.769
TTF-1 + CK7	0.960 ± 0.0231	0.718 – 0.986	0.732 ± 0.0919	0.533 – 0.967
TTF-1 + Napsin	0.858 ± 0.0420	0.875 – 1.000	0.934 ± 0.0417	0.833 – 1.000
TTF-1 + CK7 + Napsin A	0.972 ± 0.0197	0.887 – 1.000	0.737 ± 0.0850	0.500 – 0.900
Metastatic ADCs
TTF-1	0.870 ± 0.0310	0.808 – 0.946	0.870 ± 0.1243	0.500 – 1.000
Napsin A	0.702 ± 0.0647	0.559 – 0.881	1.000 ± 0.0000	1.000 – 1.000
CK7	1.000 ± 0.0000	1.000 – 1.000	0.285 ± 0.2358	0.000 – 1.000
TTF-1 + CK7	0.992 ± 0.0086	0.969 – 1.000	0.624 ± 0.1662	0.125 – 1.000
TTF-1 + Napsin	0.878 ± 0.0298	0.794 – 0.939	0.881 ± 0.1286	0.375 – 1.000
TTF-1 + CK7 + Napsin A	0.993 ± 0.0072	0.969 – 1.000	0.618 ± 0.1793	0.125 – 1.000

ADC: adenocarcinoma. SqCC: squamous cell carcinoma.

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