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Table 6 Performance of individual marker in primary and metastatic lung adenocarcinomas

From: Utility of five commonly used immunohistochemical markers TTF-1, Napsin A, CK7, CK5/6 and P63 in primary and metastatic adenocarcinoma and squamous cell carcinoma of the lung: a retrospective study of 246 fine needle aspiration cases

Type

Primary ADC (n = 72) vs

Metastatic ADC (n = 131) vs

Primary SqCC(n = 30)

Metastatic SqCC(n = 13)

Sensitivity

Specificity

PPV

NPV

Sensitivity

Specificity

PPV

NPV

TTF-1

84.5%

96.4%

98.4%

71.1%

86.9%

87.5%

99.1%

29.2%

CK7

93.8%

50.0%

86.5%

70.0%

100.0%

25.0%

97.1%

100.0%

Napsin A

92.0%

100.0%

100.0%

80.0%

67.8%

100.0%

100.0%%

13.6%

  1. ADC: adenocarcinoma. SqCC: squamous cell carcinoma. PPV: positive predictive value. NPV: negative predictive value.