PRE motifs are prominent in the
promoter and present within an enhancer downstream from the transcription start site. (A)
IL17A expression is significantly elevated in psoriasis lesions. Grey boxes outline the middle 50% of fold-change (FC) estimates for each dataset (whiskers: middle 90%; yellow symbols: extreme values). The median FC for each dataset is listed (right margin; FDR < 0.05 for red labels). (B) Sequence logos for the TFAM PRE motif significantly overrepresented in sequence regions upstream of psoriasis DEGs. The motif’s frequency is elevated within the IL17A promoter (see table). (C)
IL17A promoter (chr6, 52048984 – 52051683). TFAM motif matches (red font) and conserved elements are indicated (underlined sequence, phastcons ≥ 0.50). Yellow highlighted sequence denotes a DNase I hypersensitive site (Th17 cells).