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  • Erratum
  • Open Access
  • Erratum to: The hippo signaling pathway: implications for heart regeneration and disease

    Clinical and Translational Medicine20154:12

    • Received: 19 February 2015
    • Accepted: 19 February 2015
    • Published:

    The original article was published in Clinical and Translational Medicine 2014 3:27

    After publication of this review [1] it emerged that the references in the Introduction section were incorrect. Several references were omitted and other references were numbered incorrectly. These errors were introduced during the final production process by the publisher and SpringerOpen apologises for any inconvenience caused.

    The relevant Introduction and references have been replaced with:

    Myocardial infarction (MI), or insufficient blood flow to the heart muscle, promotes the death and loss of cardiomyocytes resulting in heart damage and impaired cardiac function. While patient survival following MI has improved, the prognosis is typically poor and can eventually progress to heart failure, a leading cause of morbidity and mortality (one). Because mature cardiomyocytes have a limited capacity to re-enter the cell cycle and proliferate [116, 117], the ability of the adult heart to regenerate is similarly restricted and cannot adequately replace lost cardiomyocytes. The Hippo signaling pathway is evolutionarily conserved from flies to mammals and has emerged as an important regulator of both cell survival and proliferation (four) [20]. Importantly, this cascade also appears critical for proper mammalian heart development and the post-natal response to cardiac stress and injury [60, 123, 124]. It is therefore plausible to hypothesize that Hippo signaling could be targeted to promote heart regeneration after MI and heart injury. This review will provide an overview of the Hippo pathway and examine its role in cardiac development, disease and regeneration.

    The omitted references can be found below:

    Reference one

    Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., Fullerton, H. J., Gillespie, C., Hailpern, S. M., Heit, J. A., Howard, V. J., Huffman, M. D., Judd, S. E., Kissela, B. M., Kittner, S. J., Lackland, D. T., Lichtman, J. H., Lisabeth, L. D., Mackey, R. H., Magid, D. J., Marcus, G. M., Marelli, A., Matchar, D. B., McGuire, D. K., Mohler, E. R., 3rd, Moy, C. S., Mussolino, M. E., Neumar, R. W., Nichol, G., Pandey, D. K., Paynter, N. P., Reeves, M. J., Sorlie, P. D., Stein, J., Towfighi, A., Turan, T. N., Virani, S. S., Wong, N. D., Woo, D., Turner, M. B., American Heart Association Statistics, C. and Stroke Statistics, S. (2014) Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation. 129, e28-e292

    Reference four

    Staley, B. K. and Irvine, K. D. (2012) Hippo signaling in Drosophila: recent advances and insights. Developmental dynamics : an official publication of the American Association of Anatomists. 241, 3–15



    Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

    Authors’ Affiliations

    New Jersey Medical School, Cardiovascular Research Institute and Department of Cell Biology and Molecular Medicine, Rutgers Newark, 07103, NJ, USA


    1. Del R. The hippo signaling pathway: implications for heart regeneration and disease. Clinical and Translational Medicine. 2014;3:27.View ArticleGoogle Scholar


    © Del Re; licensee Springer. 2015

    This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.