The transcription factor SLUG is expressed in the nuclei of mesenchymal cells in fibrotic areas. (A-D) Representative images demonstrate considerable SLUG staining in fibroblast-like cells of fibrotic areas of colonic tissue specimens derived from CD patients. SLUG is visible in the nuclei of fibroblast-like cells (black arrows) indicative for transcriptionally active SLUG protein. The insert in (A) demonstrates van-Gieson staining. Magnification: 10-fold or 40-fold, respectively. All analysed patient samples showed comparable staining characteristics when compared to samples from non-affected controls.