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Clinical and Translational Medicine
Figure 2 | Clinical and Translational Medicine

Figure 2

From: Hallmarks of epithelial to mesenchymal transition are detectable in Crohn’s disease associated intestinal fibrosis

Figure 2

Expression of TGFβ 1 in fibrotic lesions. (A + B) In representative samples from two different non-IBD control patients, the epithelial layer showed a considerable staining intensity for TGFβ1, while the staining in sub-mucosal layers was only slightly detectable. (C) In CD patients with intestinal fibrosis, expression of TGFβ1 in the epithelial layer was strongly detectable. (D-F) In fibrotic areas, sub-mucosal TGF-β1 staining is strongly detectable. Magnification: 20-fold or 40-fold, respectively. All analysed patient samples showed comparable staining characteristics when compared to samples from non-affected controls.

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