Expression of TGFβ
in fibrotic lesions. (A + B) In representative samples from two different non-IBD control patients, the epithelial layer showed a considerable staining intensity for TGFβ1, while the staining in sub-mucosal layers was only slightly detectable. (C) In CD patients with intestinal fibrosis, expression of TGFβ1 in the epithelial layer was strongly detectable. (D-F) In fibrotic areas, sub-mucosal TGF-β1 staining is strongly detectable. Magnification: 20-fold or 40-fold, respectively. All analysed patient samples showed comparable staining characteristics when compared to samples from non-affected controls.