TY - JOUR AU - Heyer, B. S. AU - Warsowe, J. AU - Solter, D. AU - Knowles, B. B. AU - Ackerman, S. L. PY - 1997 DA - 1997// TI - New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo JO - Mol Reprod Dev VL - 47 UR - https://doi.org/3.0.CO;2-M DO - 3.0.CO;2-M ID - Heyer1997 ER - TY - JOUR AU - Heyer, B. S. AU - Kochanowski, H. AU - Solter, D. PY - 1999 DA - 1999// TI - Expression of Melk, a new protein kinase, during early mouse development JO - Dev Dyn VL - 215 UR - https://doi.org/3.0.CO;2-H DO - 3.0.CO;2-H ID - Heyer1999 ER - TY - JOUR AU - Beullens, M. AU - Vancauwenbergh, S. AU - Morrice, N. AU - Derua, R. AU - Ceulemans, H. AU - Waelkens, E. AU - Bollen, M. PY - 2005 DA - 2005// TI - Substrate specificity and activity regulation of protein kinase MELK JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M507274200 DO - 10.1074/jbc.M507274200 ID - Beullens2005 ER - TY - JOUR AU - Jaleel, M. AU - Villa, F. AU - Deak, M. AU - Toth, R. AU - Prescott, A. R. AU - Aalten, D. M. AU - Alessi, D. R. PY - 2006 DA - 2006// TI - The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation JO - Biochem J VL - 394 UR - https://doi.org/10.1042/BJ20051844 DO - 10.1042/BJ20051844 ID - Jaleel2006 ER - TY - JOUR AU - Lizcano, J. M. AU - Goransson, O. AU - Toth, R. AU - Deak, M. AU - Morrice, N. A. AU - Boudeau, J. PY - 2004 DA - 2004// TI - LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 JO - EMBO J VL - 23 UR - https://doi.org/10.1038/sj.emboj.7600110 DO - 10.1038/sj.emboj.7600110 ID - Lizcano2004 ER - TY - JOUR AU - Gil, M. AU - Yang, Y. AU - Lee, Y. AU - Choi, I. AU - Ha, H. PY - 1997 DA - 1997// TI - Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells JO - Gene VL - 195 UR - https://doi.org/10.1016/S0378-1119(97)00181-9 DO - 10.1016/S0378-1119(97)00181-9 ID - Gil1997 ER - TY - JOUR AU - Corti, A. AU - Williams-Ashman, H. G. AU - Wilson, J. PY - 1975 DA - 1975// TI - Study on the inhibition of testicular polyadenylate polymerase stimulated by manganese JO - Boll Soc Ital Biol Sper VL - 51 ID - Corti1975 ER - TY - JOUR AU - Du, T. AU - Qu, Y. AU - Li, J. AU - Li, H. AU - Su, L. AU - Zhou, Q. PY - 2014 DA - 2014// TI - Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway JO - Mol Cancer VL - 13 UR - https://doi.org/10.1186/1476-4598-13-100 DO - 10.1186/1476-4598-13-100 ID - Du2014 ER - TY - JOUR AU - Nakano, I. AU - Paucar, A. A. AU - Bajpai, R. AU - Dougherty, J. D. AU - Zewail, A. AU - Kelly, T. K. PY - 2005 DA - 2005// TI - Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation JO - J Cell Biol VL - 170 UR - https://doi.org/10.1083/jcb.200412115 DO - 10.1083/jcb.200412115 ID - Nakano2005 ER - TY - JOUR AU - Badouel, C. AU - Chartrain, I. AU - Blot, J. AU - Tassan, J. P. PY - 2010 DA - 2010// TI - Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit JO - Exp Cell Res VL - 316 UR - https://doi.org/10.1016/j.yexcr.2010.04.019 DO - 10.1016/j.yexcr.2010.04.019 ID - Badouel2010 ER - TY - JOUR AU - Vulsteke, V. AU - Beullens, M. AU - Boudrez, A. AU - Keppens, S. AU - Eynde, A. AU - Rider, M. H. PY - 2004 DA - 2004// TI - Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1 JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M311466200 DO - 10.1074/jbc.M311466200 ID - Vulsteke2004 ER - TY - JOUR AU - Cordes, S. AU - Frank, C. A. AU - Garriga, G. PY - 2006 DA - 2006// TI - The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions JO - Development VL - 133 UR - https://doi.org/10.1242/dev.02447 DO - 10.1242/dev.02447 ID - Cordes2006 ER - TY - JOUR AU - Saito, R. AU - Tabata, Y. AU - Muto, A. AU - Arai, K. AU - Watanabe, S. PY - 2005 DA - 2005// TI - Melk-like kinase plays a role in hematopoiesis in the zebra fish JO - Mol Cell Biol VL - 25 UR - https://doi.org/10.1128/MCB.25.15.6682-6693.2005 DO - 10.1128/MCB.25.15.6682-6693.2005 ID - Saito2005 ER - TY - JOUR AU - Page, Y. AU - Chartrain, I. AU - Badouel, C. AU - Tassan, J. P. PY - 2011 DA - 2011// TI - A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development JO - J Cell Sci VL - 124 UR - https://doi.org/10.1242/jcs.069567 DO - 10.1242/jcs.069567 ID - Page2011 ER - TY - JOUR AU - Nakano, I. AU - Kornblum, H. I. PY - 2009 DA - 2009// TI - Methods for analysis of brain tumor stem cell and neural stem cell self-renewal JO - Methods Mol Biol VL - 568 UR - https://doi.org/10.1007/978-1-59745-280-9_4 DO - 10.1007/978-1-59745-280-9_4 ID - Nakano2009 ER - TY - JOUR AU - Marie, S. K. AU - Okamoto, O. K. AU - Uno, M. AU - Hasegawa, A. P. AU - Oba-Shinjo, S. M. AU - Cohen, T. PY - 2008 DA - 2008// TI - Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas JO - Int J Cancer VL - 122 UR - https://doi.org/10.1002/ijc.23189 DO - 10.1002/ijc.23189 ID - Marie2008 ER - TY - JOUR AU - Kig, C. AU - Beullens, M. AU - Beke, L. AU - Eynde, A. AU - Linders, J. T. AU - Brehmer, D. AU - Bollen, M. PY - 2013 DA - 2013// TI - Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells JO - J Biol Chem VL - 288 UR - https://doi.org/10.1074/jbc.M113.471433 DO - 10.1074/jbc.M113.471433 ID - Kig2013 ER - TY - JOUR AU - Horvath, S. AU - Zhang, B. AU - Carlson, M. AU - Lu, K. V. AU - Zhu, S. AU - Felciano, R. M. PY - 2006 DA - 2006// TI - Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0608396103 DO - 10.1073/pnas.0608396103 ID - Horvath2006 ER - TY - JOUR AU - Jung, H. AU - Seong, H. A. AU - Ha, H. PY - 2008 DA - 2008// TI - Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation JO - J Biol Chem VL - 283 UR - https://doi.org/10.1074/jbc.M807219200 DO - 10.1074/jbc.M807219200 ID - Jung2008 ER - TY - JOUR AU - Seong, H. A. AU - Ha, H. PY - 2012 DA - 2012// TI - Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M112.347757 DO - 10.1074/jbc.M112.347757 ID - Seong2012 ER - TY - JOUR AU - Denning, D. P. AU - Hatch, V. AU - Horvitz, H. R. PY - 2012 DA - 2012// TI - Programmed elimination of cells by caspase-independent cell extrusion in C. elegans JO - Nature VL - 488 UR - https://doi.org/10.1038/nature11240 DO - 10.1038/nature11240 ID - Denning2012 ER - TY - JOUR AU - Gu, C. AU - Banasavadi-Siddegowda, Y. K. AU - Joshi, K. AU - Nakamura, Y. AU - Kurt, H. AU - Gupta, S. AU - Nakano, I. PY - 2013 DA - 2013// TI - Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner JO - Stem Cells VL - 31 UR - https://doi.org/10.1002/stem.1322 DO - 10.1002/stem.1322 ID - Gu2013 ER - TY - JOUR AU - Lin, M. L. AU - Park, J. H. AU - Nishidate, T. AU - Nakamura, Y. AU - Katagiri, T. PY - 2007 DA - 2007// TI - Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family JO - Breast Cancer Res VL - 9 UR - https://doi.org/10.1186/bcr1650 DO - 10.1186/bcr1650 ID - Lin2007 ER - TY - JOUR AU - Giam, M. AU - Okamoto, T. AU - Mintern, J. D. AU - Strasser, A. AU - Bouillet, P. PY - 2012 DA - 2012// TI - Bcl-2 family member Bcl-G is not a proapoptotic protein JO - Cell Death Dis VL - 3 UR - https://doi.org/10.1038/cddis.2012.130 DO - 10.1038/cddis.2012.130 ID - Giam2012 ER - TY - JOUR AU - Kemp, B. E. AU - Mitchelhill, K. I. AU - Stapleton, D. AU - Michell, B. J. AU - Chen, Z. P. AU - Witters, L. A. PY - 1999 DA - 1999// TI - Dealing with energy demand: the AMP-activated protein kinase JO - Trends Biochem Sci VL - 24 UR - https://doi.org/10.1016/S0968-0004(98)01340-1 DO - 10.1016/S0968-0004(98)01340-1 ID - Kemp1999 ER - TY - JOUR AU - Kuner, R. AU - Falth, M. AU - Pressinotti, N. C. AU - Brase, J. C. AU - Puig, S. B. AU - Metzger, J. PY - 2013 DA - 2013// TI - The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer JO - J Mol Med (Berl) VL - 91 UR - https://doi.org/10.1007/s00109-012-0949-1 DO - 10.1007/s00109-012-0949-1 ID - Kuner2013 ER - TY - JOUR AU - Pickard, M. R. AU - Green, A. R. AU - Ellis, I. O. AU - Caldas, C. AU - Hedge, V. L. AU - Mourtada-Maarabouni, M. AU - Williams, G. T. PY - 2009 DA - 2009// TI - Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer JO - Breast Cancer Res VL - 11 UR - https://doi.org/10.1186/bcr2350 DO - 10.1186/bcr2350 ID - Pickard2009 ER - TY - JOUR AU - Nakano, I. AU - Masterman-Smith, M. AU - Saigusa, K. AU - Paucar, A. A. AU - Horvath, S. AU - Shoemaker, L. PY - 2008 DA - 2008// TI - Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells JO - J Neurosci Res VL - 86 UR - https://doi.org/10.1002/jnr.21471 DO - 10.1002/jnr.21471 ID - Nakano2008 ER - TY - JOUR AU - Gray, D. AU - Jubb, A. M. AU - Hogue, D. AU - Dowd, P. AU - Kljavin, N. AU - Yi, S. PY - 2005 DA - 2005// TI - Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-04-4531 DO - 10.1158/0008-5472.CAN-04-4531 ID - Gray2005 ER - TY - STD TI - Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, et al. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife 2014:e01763. ID - ref30 ER - TY - JOUR AU - Nguyen, L. V. AU - Vanner, R. AU - Dirks, P. AU - Eaves, C. J. PY - 2012 DA - 2012// TI - Cancer stem cells: an evolving concept JO - Nat Rev Cancer VL - 12 ID - Nguyen2012 ER - TY - JOUR AU - Jordan, C. T. AU - Guzman, M. L. AU - Noble, M. PY - 2006 DA - 2006// TI - Cancer stem cells JO - N Engl J Med VL - 355 UR - https://doi.org/10.1056/NEJMra061808 DO - 10.1056/NEJMra061808 ID - Jordan2006 ER - TY - JOUR AU - Hebbard, L. W. AU - Maurer, J. AU - Miller, A. AU - Lesperance, J. AU - Hassell, J. AU - Oshima, R. G. AU - Terskikh, A. V. PY - 2010 DA - 2010// TI - Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo JO - Cancer Res VL - 70 UR - https://doi.org/10.1158/0008-5472.CAN-10-1295 DO - 10.1158/0008-5472.CAN-10-1295 ID - Hebbard2010 ER - TY - JOUR AU - Dontu, G. AU - Abdallah, W. M. AU - Foley, J. M. AU - Jackson, K. W. AU - Clarke, M. F. AU - Kawamura, M. J. AU - Wicha, M. S. PY - 2003 DA - 2003// TI - In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells JO - Genes Dev VL - 17 UR - https://doi.org/10.1101/gad.1061803 DO - 10.1101/gad.1061803 ID - Dontu2003 ER - TY - JOUR AU - Joshi, K. AU - Banasavadi-Siddegowda, Y. AU - Mo, X. AU - Kim, S. H. AU - Mao, P. AU - Kig, C. PY - 2013 DA - 2013// TI - MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells JO - Stem Cells VL - 31 UR - https://doi.org/10.1002/stem.1358 DO - 10.1002/stem.1358 ID - Joshi2013 ER - TY - JOUR AU - Minata, M. AU - Gu, C. AU - Joshi, K. AU - Nakano-Okuno, M. AU - Hong, C. AU - Nguyen, C. H. PY - 2014 DA - 2014// TI - Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0092546 DO - 10.1371/journal.pone.0092546 ID - Minata2014 ER - TY - JOUR AU - Choi, S. AU - Ku, J. L. PY - 2011 DA - 2011// TI - Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression JO - Biochem Biophys Res Commun VL - 412 UR - https://doi.org/10.1016/j.bbrc.2011.07.060 DO - 10.1016/j.bbrc.2011.07.060 ID - Choi2011 ER - TY - JOUR AU - Seong, H. A. AU - Gil, M. AU - Kim, K. T. AU - Kim, S. J. AU - Ha, H. PY - 2002 DA - 2002// TI - Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38) JO - Biochem J VL - 361 UR - https://doi.org/10.1042/0264-6021:3610597 DO - 10.1042/0264-6021:3610597 ID - Seong2002 ER - TY - JOUR AU - Chung, S. AU - Nakamura, Y. PY - 2013 DA - 2013// TI - MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells JO - Cell Cycle VL - 12 UR - https://doi.org/10.4161/cc.24988 DO - 10.4161/cc.24988 ID - Chung2013 ER - TY - STD TI - Ganguly R, Hong CS, Smith LG, Kornblum HI and Nakano I. Maternal Embryonic Leucine Zipper Kinase: Key Kinase for Stem Cell Phenotype in Glioma and Other Cancers. Mol Cancer Ther 2014. ID - ref40 ER - TY - JOUR AU - Chung, S. AU - Suzuki, H. AU - Miyamoto, T. AU - Takamatsu, N. AU - Tatsuguchi, A. AU - Ueda, K. PY - 2012 DA - 2012// TI - Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer JO - Oncotarget VL - 3 ID - Chung2012 ER - TY - JOUR AU - Chien, S. C. AU - Brinkmann, E. M. AU - Teuliere, J. AU - Garriga, G. PY - 2013 DA - 2013// TI - Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions JO - Genetics VL - 193 UR - https://doi.org/10.1534/genetics.112.148106 DO - 10.1534/genetics.112.148106 ID - Chien2013 ER - TY - JOUR AU - Saito, R. AU - Nakauchi, H. AU - Watanabe, S. PY - 2012 DA - 2012// TI - Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells JO - Cancer Sci VL - 103 UR - https://doi.org/10.1111/j.1349-7006.2011.02104.x DO - 10.1111/j.1349-7006.2011.02104.x ID - Saito2012 ER - TY - JOUR AU - Tassan, J. P. PY - 2011 DA - 2011// TI - Cortical localization of maternal embryonic leucine zipper kinase (MELK) implicated in cytokinesis in early xenopus embryos JO - Commun Integr Biol VL - 4 UR - https://doi.org/10.4161/cib.15669 DO - 10.4161/cib.15669 ID - Tassan2011 ER -