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Table 1 Advantages and disadvantages of anti-cancer therapies targeting macrophage behaviors

From: The significance of macrophage phenotype in cancer and biomaterials

Approach Advantages Disadvantages
Anti-angiogenic therapy Inhibit tumor growth and prevent metastasis [33],[34], improves efficacy of chemotherapeutics [35] Must be used in combination with chemotherapeutics [36]; systemic effects [36],[37]
Recruitment inhibition Prevent macrophages from entering tumor, becoming TAMs [38],[39] Systemic effects [38]
Macrophage reprogramming Macrophages secrete tumoricidal molecules [40],[41] Local delivery necessary to avoid altering systemic Th1/Th2 paradigm [42]