From: The translational significance of epithelial-mesenchymal transition in head and neck cancer
Marker | Prognosis | Viral-association | Biomarker type | Study power | Concomitant markers | Reference (s) |
---|---|---|---|---|---|---|
Classic EMT pathways implicited | ||||||
Snail 1 | Poor PFS;⬆ TNM; ⬆ Metastasis; Proinflammatory | EBV47 | IHC | N = 147 [49] | NBS; HIF1α (Hypoxia) E-/N Cadherin (Class switching) | |
In vitro | N = 733 [51] | |||||
N = 42 [50] | ||||||
Snail 2 (Slug) | ⬆ TNM; ⬆ Metastasis; ⬆ OS |  | IHC | N = 119 [52] | HIF1α | |
In vitro | ||||||
TWIST | Poor PFS; ⬆ Metastasis; ⬆ OS; ⬆Positive Nodal status |  | IHC | N = 147 [49] | HIF1α; Snail | |
In vitro | N = 109 [54] | |||||
N = 69 [55] | ||||||
SIP1 | ⬆ Delayed-type neck metastasis |  | IHC | N = 37 [56] |  | [56] |
In vitro | ||||||
ZEB | -- | Â | In vitro | -- | Â | Â |
Canonical Developmental Pathways Implicated | ||||||
Notch/Jagged/DLL4 | -- |  | Sequencing | N = 56 [57] | Hes/Hey1 | [57] |
Wnt/β-Catenin | -- |  | IHC | N = 374 [58] |  | [58] |
In vitro | ||||||
Shh/GLI-1 | ⬆ Cetuximab resistance |  | In vitro |  |  | [59] |
Viral EMT Pathways Implicated | ||||||
Vimentin | -- | HPV | IHC | N = 69 [55] | TWIST1/2; Snail; Slug | [55] |
In vitro | ||||||
TGF-β | -- | HPV | IHC | N = 140 [60] | TGFβR1/R2 | |
In vitro | N = 200 [61] |