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Clinical and Translational Medicine
Figure 1 | Clinical and Translational Medicine

Figure 1

From: Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers

Figure 1

Schematic illustration of the Ct-OATP1B3 cDNA structure and its predicted translation products. (A) The cDNA structures of Ct- and Lt-OATP1B3 along with their predicted translation products were shown. The sky-blue boxes indicate the Lt-OATP1B3-specific exons, while the blue box indicates the Ct-OATP1B3-specific exon. The white boxes indicate the common exons. Each exon number is shown in the box. The translation product of Lt-OATP1B3 or the predicted translation products of Ct-OATP1B3 (Ct-OATP1B3-C and Ct-OATP1B3-v1) are shown below the cDNA structures. The red and black triangles indicate the translation start and stop codons, respectively. The open and closed arrows indicate an isoform-specific primer set for Lt-OATP1B3 or Ct-OATP1B3 detection, respectively. (B) The 5’-end cDNA sequence of Ct-OATP1B3 (exon 1* to 3) was shown. The bold blue letters indicate the predicted translation start codon (ATG) of Ct-OATP1B3-C or Ct-OATP1B3-v1. The underlines indicate the key sequences supposedly determining translation efficiency, while the consensus Kozak sequence is 5’-A/GNNatgG-3’, where small “atg” is the translation start codon.

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