Skip to main content
Figure 3 | Clinical and Translational Medicine

Figure 3

From: Targeting met mediated epithelial-mesenchymal transition in the treatment of breast cancer

Figure 3

Schematic representation of HGF/Met-mediated epithelial mesenchymal transition (EMT) and promotion of malignant progression. HGF-mediated Met activation and signaling can induced multiple pathways that are involved in stimulating cancer cell proliferation, survival, motility, angiogenesis, invasion and metastasis. Normal epithelial cells display a highly differentiated morphology characterized by a single layer of cells anchored by their basal lamina to the extracellular matrix. Aberrant Met activity will stimulate cell proliferation and EMT that ultimately results in changes in morphology and behavior, characteristic of a mesenchymal-like phenotype. EMT allows cancerous epithelial cells to become more mobile, invasive and metastatic in nature.

Back to article page