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Clinical and Translational Medicine
Figure 4 | Clinical and Translational Medicine

Figure 4

From: Transcriptional factor snail controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma

Figure 4

OP treatment of RAGxCγ double mutant mice bearing heterotopic xenograft of A2780 tumors. A2780 cells at 0.5 × 106 in 0.2 mL were implanted cutaneously in the right back flank of these mice. Twice a week following implantation of the cancer cells each mouse was monitored for tumor volume ((width square/2) × length) at the site of implantation. Mice were treated with 30 and 50 mg/kg of OP in sterile saline i.p. daily at day 7 post-implantation when the tumor volume reached approximately 50 mm3. (A) Tumor growth rates for individual mice (mouse label A1-4 for the control cohort; B1-4, 50mg/kg OP cohort and C1-4, 30mg/kg cohort). (B) Representative tumors on the right flank of the individual animals at end-point, necropsy of live tumors, H&E staining and immunostaining for mouse CD31+ (PECAM-1) cells of tumor tissues.

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