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Table 2 Salivary Concentrations of IL-6 and IL-8 (pg/ml) in OSCC, OLP, and chronic periodontitis patient groups

From: A review of research on salivary biomarkers for oral cancer detection

Author/reographical region/year OSCC OLP Chronic periodontitis Controls
IL-6 IL-8 IL-6 IL-8 IL-6 IL-8 IL-6 IL-8
St. John et al./California, USA/2004[23]   720     250
Rhodus et al./Minnesota, USA/2005[24] 88.2± 43.2 3154.1±1023.2    1.4±0.9 1580± 789
Rhodus et al./Minnesota, USA/2005[67]   371.35±205.52 2194.3± 496.7   47.46±18.74 703.8± 131.6
Katakura et al./Tokyo, Japan/2007[34] 86.5 720    0 250
Zhang et al./Sichuan, China/2008[69]   48.79±8.53 1737.49±1073.54   29.9±4.68 641.46±172.91
Saheb Jamee et al./Tehran, Iran/2008[35] 40.9± 79.5 1093.7±1089.0    2.5±1.3 700.7± 1031.5
Arellano- Garcia et al./California, USA/2008[70]   3347.7±2929     759.4± 563
Teles et al./Massachusetts, USA/2009[68]     2268±111   1945±181
Sharma et al./Manipal, India/2011[71]    311.35±11.51   17.15±8.44  
Ebersole et al./Kentucky, USA/2013[72]    35.57±48.17   3.30±2.32  
Cheng et al./Texas, USA/2014[38] 178.41±172.32 1525.33±1123.95 20.74±22.28 1328.37±731.80 5.85±4.02 738.79±394.00 4.92±8.77 890.83±563.22
  1. All studies investigated unstimulated whole saliva.