A review of research on salivary biomarkers for oral cancer detection

Clinical and Translational Medicine

Table 2 Salivary Concentrations of IL-6 and IL-8 (pg/ml) in OSCC, OLP, and chronic periodontitis patient groups

Author/reographical region/year	OSCC		OLP		Chronic periodontitis		Controls
Author/reographical region/year	IL-6	IL-8	IL-6	IL-8	IL-6	IL-8	IL-6	IL-8
St. John et al./California, USA/2004[23]		720						250
Rhodus et al./Minnesota, USA/2005[24]	88.2± 43.2	3154.1±1023.2					1.4±0.9	1580± 789
Rhodus et al./Minnesota, USA/2005[67]			371.35±205.52	2194.3± 496.7			47.46±18.74	703.8± 131.6
Katakura et al./Tokyo, Japan/2007[34]	86.5	720					0	250
Zhang et al./Sichuan, China/2008[69]			48.79±8.53	1737.49±1073.54			29.9±4.68	641.46±172.91
Saheb Jamee et al./Tehran, Iran/2008[35]	40.9± 79.5	1093.7±1089.0					2.5±1.3	700.7± 1031.5
Arellano- Garcia et al./California, USA/2008[70]		3347.7±2929						759.4± 563
Teles et al./Massachusetts, USA/2009[68]						2268±111		1945±181
Sharma et al./Manipal, India/2011[71]					311.35±11.51		17.15±8.44
Ebersole et al./Kentucky, USA/2013[72]					35.57±48.17		3.30±2.32
Cheng et al./Texas, USA/2014[38]	178.41±172.32	1525.33±1123.95	20.74±22.28	1328.37±731.80	5.85±4.02	738.79±394.00	4.92±8.77	890.83±563.22