Skip to main content

Advertisement

Table 1 Potential salivary biomarkers for oral cancer detection, reported as of 2013

From: A review of research on salivary biomarkers for oral cancer detection

Category Potential OSCC salivary biomarkers Authors/year
Non-organic compound Na, Ca, F, and Mg Shpitzer et al./2007 [55]
Peptide Defensin-1 Mizukawa et al./1998 [28]
Proteins P53 autoantibody Warnakulasuriya et al./2000 [19]
α-amylase Chen et al./2002 [20]
IL-8 St. John et al./2004 [23]
Rhodus et al./2005 [24]
Arellano-Garcia et al./2008 [70]
Brinkmann et al./2011 [43]
Elashoff et al./2012 [44]
TNF-α Rhodus et al./2005 [24]
IL-1
IL-6 Rhodus et al./2005 [24]
Katakura et al./2007 [34]
Saheb-Jamee et al./2008 [35]
Sato et al./2010 [36]
Cheng et al./2013 [38]
Basic fibroblast growth factor Vucicevic et al./2005 [27]
Gorugantula et al./2012 [39]
Statherin Contucci et al./2005 [62]
Cyfra 21.1 Nagler et al./2006 [25]
Tissue polypeptide antigen (TPA)
Cancer antigen 125 (CA125) Nagler et al./2006 [25]
Balan et al./2012 [57]
Endothelin-1 Pickering et al./2007 [21]
Cheng et al./2011 [40]
IL-1β Katakura et al./2007 [34]
Brinkmann et al./2011 [43]
Elashoff et al./2012 [44]
CD44 Franzmann et al./2007 [46]
Total salivary protein Shpitzer et al./2007 [55]
Insulin growth factor 1 (IGF-1)
MMP-2
MMP-9 Shpitzer et al./2007, 2009 [49, 55]
CD59 Hu et al./2008 [29]
Catalase
Profilin
S100A9/MRP14
M2BP Hu et al./2008 [29]
Brinkmann et al./2011 [43]
Elashoff et al./2012 [44]
Carcinoembryonic antigen (CEA) He et al./2009 [54]
Carcinoma associated antigen CA-50
Salivary carbonyls Shipitzer et al./2009 [49]
Cyclin D1
Maspin
8-oxoguanine DNA glycosylase (OGG1)
Phosphorylated-Src
Ki-67
Lactate dehydrogenase Shipitzer et al./2009 [49]
Shetty et al./2012 [58]
Transferrin Jou et al./2010 [45]
Zinc finger protein 501 peptide Jou et al./2011 [60]
Hemopexin Jessie et al./2013 [59]
Haptoglobin
Complement C3
Transthyretin
α1-antitrypsin
DNAs P53 gene codon 63 Liao et al./2000 [18]
Loss of heterozygosity in the combination of markers D3S1234, D9S156, and D17S799 El-Naggar et al./2001 [51]
Mitochondrial DNAs (cytochrome c oxidase I and cytochrome c oxidase II) Jiang et al./2005 [37]
Hypermethylation of promoters in tumor suppressor genes: DAPK, DCC, MINT-31, TIMP-31, TIMP-3, p16, MGMT, CCNA1 Carvalho et al./2011 [61]
mRNAs IL-8 Li et al./2004 [22]
Brinkmann et al./2011 [43]
Elashoff et al./2012 [44]
IL-1β Li et al./2004 [22]
Elashoff et al./2012 [44]
DUSP1 (dual specificity phosphatase 1) Li et al./2004 [22]
Elashoff et al./2012 [44]
Cheng et al./2013 [41]
H3F3A (H3 histone family 3A) Li et al./2004 [22]
Elashoff et al./2012 [44]
OAZ1 (ornithin decarboxylase antizyme 1) Li et al./2004 [22]
Elashoff et al./2012 [44]
Cheng et al./2013 [41]
S100P (S100 calcium binding protein P) Li et al./2004 [22]
Brinkmann et al./2011 [43]
Elashoff et al./2012 [44]
Cheng et al./2013 [41]
SAT (spermidine/spermine N1-acetyltransferase EST) Li et al./2004 [22]
Brinkmann et al./2011 [43]
Elashoff et al./2012 [44]
MicroRNAs miR-125a Park et al./2009 [31]
miR-200a
miR-31 Liu et al./2012 [33]
Long non-coding RNAs HOTAIR Tang et al./2013 [56]
Oxidative stress-related molecules Reactive nitrogen species (RNS) such as nitric oxide (NO), nitrites (NO2) and nitrates (NO3) Bahar et al./2007 [26]
Peroxidase Bahar et al./2007 [26]
Glutathione S-transferase (GST) Bahar et al./2007 [26]
Superoxide dismutase (SOD) Agha-Hosseini et al./2012 [52]
8-hydroxy-2-deoxyguanosine (8-OHdG)
Glutathione Almadori et al./2007 [30]
Malondialdehyde (MDA) Agha-Hosseini et al./2012 [52]
Glucocorticoid Cortisol Bernabé et al./2012 [53]
Metabolomics Cadaverine, alpha-aminobutyric acid, alanine, C5H14N5, piperidine, taurine piperideine, pipercolic acid, C4H9N, C8H9N, pyrroline hydroxycarboxylic acid, betaine, C6H6N2O2, leucine+isoleucine, tyrosine, histidine, tryptophan, beta-alanine, glutamic acid, threonine, serine, glutamine, choline, carnitine, C4H5N2O11P Sugimoto et al./2010 [47]
Phenylalanine Wei et al./2011 [48]
Sugimoto et al./2010 [47]
Valine Wei et al./2011 [48]
Sugimoto et al./2010 [47]
Lactic acid Wei et al./2011 [48]
Glycosylation- related molecules Sialic acid Vajaria et al./2013 [32]
α-L-fucosidase
Other Telomerase activity Zhong et al./2005 [50]