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Table 2 MiRNAs and key molecules in signaling pathways reported for gliobastoma multiforme

From: Stem cell delivery of therapies for brain disorders

Target

miRNA

Pathway/Process

References

EGFR

miR-7

EGFR signaling

[80]

PTEN

miR-21

Cell-cycle progression, Apoptosis

[75]

PTEN

miR-26a

Akt pathway

[76]

Notch1/Notch2

miR-326

Notch pathway

[78]

IκB

miR-218

IKK-β/NF-κB pathway

[77]

STAT1/STAT2

miR-221/miR-222

IFN-α signaling pathway

[81]

CDK6

miR-124/miR-137

Cell cycle arrest

[82]

Bmi-1

miR-128

Bmi-1 decrease

[83]

Akt1, CyclinD1, MMP-2, MMP-9, Bcl-2

miR-451

Tumor suppression

[84]

  1. Table shows representative examples of how specific molecules are regulated by miRNAs, and to provide insights on how the information can be used to develop treatment strategies.