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Table 1 Summary of non-cancer mammalian pathologies in which MST1/2 kinases are involved

From: The Hippo pathway in disease and therapy: cancer and beyond

Tissue Protein Model Pathology References
Liver MST1/2 MST1/2 mutant conditional mouse Hepatomegaly [16, 45, 46]
Heart MST1 Mouse model of Arrhythmogenic Cardiomyopathy and human samples Arrhythmogenic Cardiomyopathy [47]
Neonatal rat ventricular myocytes Heart failure, ischemic heart disease, dilated cardiomyopathy and cardiomyocyte apoptosis [4850]
Dominant negative MST1 mice and MST1 -/- mice Cardiac dysfunction [51]
Muscle MST1 MST1 deficient mice Neurogenic muscle atrophy [52]
Brain MST1 Mouse model of Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis (ALS) [53]
Pancreas MST1/2 MST1/2 mutant conditional mouse Reduction of pancreatic mass, exocrine pancreas disorganization and pancreatitis-like autodigestion [54, 55]
Thymus MST1 MST1 deficient patients or with homozygous mutations Immunodeficiency, T and B cells lymphopenia [21, 56]
MST1 deficient mice Defective lymphocyte trafficking and thymocyte egress. Autoimmune-like disorders. Impaired development and function of regulatory T cells. Low numbers of mature naïve T cells. [5760]
MST1/2 MST1 and MST2 deficient mice Autoimmune disease (skin lesions around the eyes, lymphocytes infiltration, colitis) [17, 61]
Lung MST1/2 MST1/2 mutant conditional mouse Respiratory distress syndrome [62]
MST1 Rat model of Hypoxic pulmonary vascular remodelling Pulmonary arterial hypertension [63]