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Table 1 Summary of non-cancer mammalian pathologies in which MST1/2 kinases are involved

From: The Hippo pathway in disease and therapy: cancer and beyond

Tissue

Protein

Model

Pathology

References

Liver

MST1/2

MST1/2 mutant conditional mouse

Hepatomegaly

[16, 45, 46]

Heart

MST1

Mouse model of Arrhythmogenic Cardiomyopathy and human samples

Arrhythmogenic Cardiomyopathy

[47]

Neonatal rat ventricular myocytes

Heart failure, ischemic heart disease, dilated cardiomyopathy and cardiomyocyte apoptosis

[48–50]

Dominant negative MST1 mice and MST1 -/- mice

Cardiac dysfunction

[51]

Muscle

MST1

MST1 deficient mice

Neurogenic muscle atrophy

[52]

Brain

MST1

Mouse model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS)

[53]

Pancreas

MST1/2

MST1/2 mutant conditional mouse

Reduction of pancreatic mass, exocrine pancreas disorganization and pancreatitis-like autodigestion

[54, 55]

Thymus

MST1

MST1 deficient patients or with homozygous mutations

Immunodeficiency, T and B cells lymphopenia

[21, 56]

MST1 deficient mice

Defective lymphocyte trafficking and thymocyte egress. Autoimmune-like disorders. Impaired development and function of regulatory T cells. Low numbers of mature naïve T cells.

[57–60]

MST1/2

MST1 and MST2 deficient mice

Autoimmune disease (skin lesions around the eyes, lymphocytes infiltration, colitis)

[17, 61]

Lung

MST1/2

MST1/2 mutant conditional mouse

Respiratory distress syndrome

[62]

MST1

Rat model of Hypoxic pulmonary vascular remodelling

Pulmonary arterial hypertension

[63]