Table 5 Selected hematology and biochemistry analysis of female C57BL/6 J mice following single or repeated injections of MSC-NTF cells or the vehicle control
Treatment | ||||
|---|---|---|---|---|
4-week study | 8-week study | 12-week study | ||
Parameter | MSC-NTF cells single injection | MSC-NTF cells 2 injections | MSC-NTF cells 3 injections | Vehicle 3 injections |
No of animals analyzed | 5 | 5 | 5 | 5 |
White blood cells (×103/μL) | 11.1 (2.4) | 8.5 (1.9) | 9.2 (3.0) | 9.0 (1.6) |
Red blood cells (×106/μL) | 9.74 (0.31) | 9.65 (0.41) | 8.37* (1.66) | 10.97 (0.81) |
Hemoglobin (g/dL) | 14.7 (0.3) | 15.1 (0.5) | 12.9* (3.1) | 17.0 (1.4) |
HCT (%) | 49.3 (1.5) | 49.4 (2.1) | 41.9* (8.1) | 55.4 (4.5) |
MCV (U3) | 50.6 (0.9) | 51.2 (0.8) | 50.1 (1.1) | 50.5 (0.7) |
Creatinine (mg/dL) | 0.22 (0.0) | 0.21 (0.04) | 0.22 (0.03) | 0.21 (0.04) |
Urea (mg/dL) | 44.0 (2.3) | 33.4 (4.3) | 45.1 (4.6) | 48.0 (5.2) |
Total Protein (g/dL) | 5.61 (0.12) | 5.94 (0.17) | 5.81 (0.35) | 5.63 (0.12) |
AST (IU/L) | 224 (140) | 186 (46) | 109 (38) | 95 (28) |
ALT (IU/L) | 288 (154) | 79 (42) | 69 (27) | 46 (11) |
ALP (IU/L) | 161 (7) | 146 (9) | 117 (24) | 124 (17) |
Bilirubin (mg/dL) | 0.11 (0.03) | 0.09 (0.01) | 0.07 (0.01) | 0.08 (0.01) |
Cholesterol (mg/dL) | 101 (9) | 111 (12) | 96 (20) | 103 (13) |
TRIG (mg/dL) | 126 (6) | 54 (9) | 58 (14) | 58 (3) |
Phosphorus (mg/dL) | 10.4 (0.8) | 10.7 (0.9) | 10.7 (1.4) | 10.8 (1.3) |
LDH (IU/L) | 921 (450) | 784 (163) | 693* (142) | 461 (86) |