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Table 3 Body weight and selected organ weights of male and female C57BL/6 J mice following single or repeated injections of MSC-NTF cells or the vehicle control

From: Safety of repeated transplantations of neurotrophic factors-secreting human mesenchymal stromal stem cells

Treatment

 

4-week study

8-week study

12-week study

Parameter

MSC-NTF cells single injection

MSC-NTF cells 2 injections

MSC-NTF cells 3 injections

Vehicle 3 injections

Males

    

 Terminal body weight (g)

26.2 (0.73)

27.4 (1.21)

30.3 (1.63)

33.6 (2.78)

Organ weight (g)

 Brain

0.463 (0.012)

0.447 (0.015)

0.468 (0.018)

0.454 (0.03)

 Liver

1.437 (0.12)

1.431 (0.114)

1.515 (0.239)

1.828 (0.214)

 Lungs

0.188 (0.044)

0.205 (0.022)

0.219 (0.036)

0.205 (0.036)

 Heart

0.141 (0.01)

0.154 (0.009)

0.178 (0.041)

0.175 (0.013)

 Spleen

0.068 (0.019)

0.08 (0.019)

0.093 (0.019)

0.094 (0.022)

Organ weight to body weight ratio (mg organ weight/g body wt)

 Brain

17.69 (0.85)

16.29 (0.52)

15.45 (0.98)

13.62 (1.7)

 Liver

54.77 (3.66)

52.15 (3.44)

49.88 (6.85)

54.38 (1.99)

 Lungs

7.16 (1.51)

7.48 (0.94)

7.24 (1.34)

6.16 (1.28)

 Heart

5.39 (0.36)

5.64 (0.42)

5.86 (1.22)

5.23 (0.43)

 Spleen

2.58 (0.67)

2.95 (0.79)

3.06 (0.6)

2.84 (0.82)

Females

    

 Terminal body weight (g)

21.9 (1.07)

21.3 (0.90)

23.5 (1.69)

22.7 (0.78)

Organ weight (g)

 Brain

0.443 (0.016)

0.444 (0.026)

0.474 (0.008)

0.462 (0.017)

 Liver

1.078 (0.1)

1.051 (0.071)

1.166 (0.124)

1.080 (0.09)

 Lungs

0.195 (0.035)

0.167 (0.02)

0.182 (0.034)

0.194 (0.021)

 Heart

0.124 (0.012)

0.144 (0.008)

0.147* (0.01)

0.131 (0.011)

 Spleen

0.088 (0.013)

0.076 (0.006)

0.112 (0.039)

0.097 (0.024)

Organ weight to body weight ratio (mg organ weight/g body wt)

 Brain

20.19 (0.38)

20.85 (1.88)

20.23 (1.33)

20.36 (0.44)

 Liver

49.05 (2.19)

49.24 (2.09)

49.56 (3.72)

47.52 (2.77)

 Lungs

8.84 (1.39)

7.84 (1.0)

7.72 (1.24)

8.56 (0.92)

 Heart

5.67 (0.37)

6.73 (0.42)

6.28 (0.35)

5.78 (0.55)

 Spleen

4.02 (0.38)

3.55 (0.25)

4.82 (1.88)

4.28 (0.94)

  1. Note: Values are mean (SD).
  2. *Indicates statistical significance at p ≤ 0.05.