Treatment | ||||
---|---|---|---|---|
4-week study | 8-week study | 12-week study | ||
Parameter | MSC-NTF cells single injection | MSC-NTF cells 2 injections | MSC-NTF cells 3 injections | Vehicle 3 injections |
Males | ||||
Terminal body weight (g) | 26.2 (0.73) | 27.4 (1.21) | 30.3 (1.63) | 33.6 (2.78) |
Organ weight (g) | ||||
Brain | 0.463 (0.012) | 0.447 (0.015) | 0.468 (0.018) | 0.454 (0.03) |
Liver | 1.437 (0.12) | 1.431 (0.114) | 1.515 (0.239) | 1.828 (0.214) |
Lungs | 0.188 (0.044) | 0.205 (0.022) | 0.219 (0.036) | 0.205 (0.036) |
Heart | 0.141 (0.01) | 0.154 (0.009) | 0.178 (0.041) | 0.175 (0.013) |
Spleen | 0.068 (0.019) | 0.08 (0.019) | 0.093 (0.019) | 0.094 (0.022) |
Organ weight to body weight ratio (mg organ weight/g body wt) | ||||
Brain | 17.69 (0.85) | 16.29 (0.52) | 15.45 (0.98) | 13.62 (1.7) |
Liver | 54.77 (3.66) | 52.15 (3.44) | 49.88 (6.85) | 54.38 (1.99) |
Lungs | 7.16 (1.51) | 7.48 (0.94) | 7.24 (1.34) | 6.16 (1.28) |
Heart | 5.39 (0.36) | 5.64 (0.42) | 5.86 (1.22) | 5.23 (0.43) |
Spleen | 2.58 (0.67) | 2.95 (0.79) | 3.06 (0.6) | 2.84 (0.82) |
Females | ||||
Terminal body weight (g) | 21.9 (1.07) | 21.3 (0.90) | 23.5 (1.69) | 22.7 (0.78) |
Organ weight (g) | ||||
Brain | 0.443 (0.016) | 0.444 (0.026) | 0.474 (0.008) | 0.462 (0.017) |
Liver | 1.078 (0.1) | 1.051 (0.071) | 1.166 (0.124) | 1.080 (0.09) |
Lungs | 0.195 (0.035) | 0.167 (0.02) | 0.182 (0.034) | 0.194 (0.021) |
Heart | 0.124 (0.012) | 0.144 (0.008) | 0.147* (0.01) | 0.131 (0.011) |
Spleen | 0.088 (0.013) | 0.076 (0.006) | 0.112 (0.039) | 0.097 (0.024) |
Organ weight to body weight ratio (mg organ weight/g body wt) | ||||
Brain | 20.19 (0.38) | 20.85 (1.88) | 20.23 (1.33) | 20.36 (0.44) |
Liver | 49.05 (2.19) | 49.24 (2.09) | 49.56 (3.72) | 47.52 (2.77) |
Lungs | 8.84 (1.39) | 7.84 (1.0) | 7.72 (1.24) | 8.56 (0.92) |
Heart | 5.67 (0.37) | 6.73 (0.42) | 6.28 (0.35) | 5.78 (0.55) |
Spleen | 4.02 (0.38) | 3.55 (0.25) | 4.82 (1.88) | 4.28 (0.94) |