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Figure 2 | Clinical and Translational Medicine

Figure 2

From: SOX2 and cancer: current research and its implications in the clinic

Figure 2

Influence of SOX2 on oncogenic-related processes and transcription. (A) SOX2 is an important regulator of cellular processes related to cancer. Some of these processes include but aren’t limited to WNT/β-CATENIN signaling, EMT and JAK/STAT3 signaling. In most cases, SOX2 functions downstream in the nucleus. SOX2’s activity leads to further downstream effects and finally alters cellular phenotypes such as cellular survival, invasion and metastasis. (B) SOX2 is typically regulating processes downstream on a transcriptional level. There are several examples of SOX2 influencing cancer phenotypes by repressing or activating particular target genes including EMT promotion via binding to the promoter regions of SNAIL, SLUG and TWIST. Therefore, SOX2 functions in cancer as a key transcription factor.

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